Name: Eisai Japan Juvela N Tocopherol Nicotinate Soft Gel Capsules (Tocopherol nicotinate) 200 mg: 100 capsules Varicose Veins, Arteriosclerosis
SKU: 3384
Price: 268 HKD
Availability: InStock

描述

Microcirculation Activator | Vitamin E Nicotinate | Direct Shipping from Overseas (Direct from Japan)

Yubela N Capsules / Soft Capsules
Juvela N Capsules / Soft Capsules

Tocopheryl Nicotinate Softgels

Package Insert No. 2190006M1156_1_02 | Company Code 170033
Prepared in July 2023 (1st Edition)

Symptoms Associated with Hypertension | Hyperlipidemia | Peripheral Circulatory Disorders Due to Arteriosclerosis |

Product Details / Approvals, etc.

Japan Standard Commodity Classification Code	87219
Pharmacological Classification Name	Microcirculation Enhancer
General Name	Tocopherol Nicotinic Acid Ester Preparation
Capsule 100 mg	YJ 2190006M1156 Approved 21800AMX10555000 Sales began in January 1967 Hard capsule No. 3, 16.2 mm long / 257 mg, Identification: EN100 The top half is opaque red, and the bottom half is white
Soft Gel Capsules, 200 mg	YJ 2190006M2179 Approved 21800AMX10556000 Sales began July 1984 Orange soft gel capsules, 14.7 × 7.2 mm / weight 471 mg, imprinted with “Yubela N200”
Storage Instructions / Expiration Date	Store at room temperature / 3 years
Manufacturing and Sales Yuan	Eisai Co., Ltd. 4-6-10 Koishikawa, Bunkyo Ward, Tokyo
Packaging	100 mg: PTP 100/1,000 tablets; bulk 500 tablets 200 mg: PTP 100/210/1,000 tablets
Shipping method	Direct overseas shipping (Direct shipping from Japan)
Preparation and shipping time	Once payment is confirmed, we typically ship the order within 4 to 7 business days.

1. Composition and Physical and Chemical Properties (3/19)

Each capsule contains 100 mg or 200 mg of tocopherol nicotinic acid ester. Contains Yellow No. 5; soft capsules also contain ethyl p-hydroxybenzoate and propyl p-hydroxybenzoate.

C₃₅H₅₃NO₃　Molecular weight 535.80; yellow to orange-yellow liquid or solid; practically insoluble in water; decomposes upon exposure to light.

Structural Formula

2. Mechanism of Action (18.)

It has antioxidant, lipid metabolism-improving, microcirculation-stimulating, vasoprotective, and antiplatelet effects; however, the mechanisms of action are not fully understood. It can lower total cholesterol and lipid peroxides while raising HDL levels; it acts directly on vascular smooth muscle to increase blood flow to the auricle; it improves microvascular permeability; it inhibits platelet aggregation induced by epinephrine, arachidonic acid, collagen, and ADP; and it can increase the partial pressure of oxygen in the blood.

3. Indications and Usage (4./6.)

Indications:Symptoms associated with hypertension; hyperlipidemia; peripheral circulatory disorders such as atherosclerotic occlusive disease.

The usual daily dose for adults is 300–600 mg of tocopherol nicotinic acid ester, taken orally in three divided doses; the dose may be adjusted based on age and symptoms.
100 mg hard capsules: 3 to 6 capsules per day | 200 mg soft capsules: usually 3 capsules per day.

4. Pharmacokinetics and Clinical Applications

Single 600 mg dose after a meal: The unchanged drug reached peak concentration in approximately 6 hours (Cmax 0.615 μg/mL, t½ 4.3 h); α-tocopherol reaches peak concentration in approximately 10 hours (Cmax 1.62 μg/mL, t½ 38.5 h). Postprandial Cmax and AUC are approximately 32-fold and 29-fold higher than those observed in the fasted state, respectively; absorption is strongly affected by food intake.

Plasma Concentration Curve

Symptoms associated with hypertension—such as numbness in the hands and feet, dizziness, stiffness in the shoulders and neck, headaches, insomnia, tinnitus, and cold extremities—may improve; thermal imaging of cold extremities in the elderly showed moderate to significant improvement with 60%. After 2 months of treatment for hyperlipidemia, total cholesterol levels decreased, HDL levels increased, and lipid peroxides decreased. It has also demonstrated efficacy in treating peripheral circulatory disorders such as obstructive arteriosclerosis.

5. Precautions and Side Effects

Administer to pregnant women only when the benefits outweigh the risks. Use during breastfeeding requires careful consideration. No clinical trials have been conducted in children.

Gastrointestinal (0.1–51 TP3T, less than): Loss of appetite, stomach discomfort, stomach pain, nausea, diarrhea, constipation. Allergic reactions (0.1–1 TP3T, less than): Rash. Liver (0.1–1 TP, less than 3 TP): Elevated AST/ALT levels. Other: Sensation of warmth, flushing; facial edema and edema may occur, frequency unknown.

PTP must be removed from the blister pack before use. Once the aluminum pouch containing the soft capsules has been opened, keep it away from high temperatures and moisture, as the coating may soften or stick together.

22–26. Other Official Information

22. 100 mg: PTP packs of 100 or 1,000 tablets; bulk packs of 500 tablets | 200 mg: PTP packs of 100, 210, or 1,000 tablets

24. Eisai Co., Ltd. hhc Hotline Toll-Free Number 0120-419-497

26. Manufacturer and Distributor: Eisai Co., Ltd., 4-6-10 Koishikawa, Bunkyo-ku, Tokyo

※ This page was translated by Hkeemall based on PMDA Package Insert 2190006M1156_1_02; it is not a substitute for a doctor’s prescription or the original Japanese version.
Enter "Yubela N" in the PMDA "Package Insert Information" search field to view the original version.

[Disclaimer]

The information regarding medications, treatments, or health management contained in this article is compiled from international authoritative medical journals and official clinical literature, and is intended for general science and educational reference only.
The indications, side effects, and contraindications of related medications may vary depending on national regulations and individual physical conditions. Do not blindly take medication on your own or change your treatment plan.
The author and publishing platform assume no legal liability for any medical delays, adverse reactions, or direct or indirect losses caused by the use of the information in this article. All medical decisions should be discussed with your attending physician before being made.

Additional information

Specifications	Eisai Juvela-N Yubela N Soft 200 mg

1 review for 日本衛材 Juvela N 生育酚烟酸酯軟膠囊（Tocopherol nicotinate）200mg：100錠静脉曲張動脉硬化

5.00

Rated 5.00 out of 5 based on 1 customer rating

Average of 1 review

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Rated 5 out of 5

Kiki Wong – August 27, 2026

Being older with poor blood circulation, after taking it, my legs are less prone to cramps, I can handle cold showers, and I feel much more comfortable.