Name: Santen Japan UPNEEQ Meimuli Upneek Hydrochloride of Hydroxymethazoline Upneek Mini Eye Drops 0.1% Mini: 30 bottles Eye Drops Eye Medication Upneek Eye Drops
SKU: 5656
Price: 520 HKD
Availability: InStock

描述

Direct overseas shipping (Direct shipping from Japan)

Upneek Mini Eye Drops 0.11 TP3T
UPNEEQ Mini Ophthalmic Solution 0.1%

Package Insert No. 131970CQ1020_1_03 | Company Code 300237
Prepared in December 2025 (1st Edition) / Revised in March 2026 (2nd Edition)

Treatment for Acquired Ptosis | Eye Drops for Müller Muscle Stimulation and Eyelid Elevation | Oxymetazoline Hydrochloride

UPNEEQ Oxymetazoline Hydrochloride Ophthalmic Solution

Product Details / Approvals, etc.

Japan Standard Commodity Classification Code	871319
Pharmacological Classification Name	Treatment for Acquired Ptosis (Müller Muscle Action · Eye Drops for Eyelid Elevation)
General Name	Oxymetazoline Hydrochloride Eye Drops Oxymetazoline Hydrochloride
Product Name	Upneek Mini Eye Drops 0.11 TP3T UPNEEQ Mini Ophthalmic Solution
YJ Code	131970CQ1020
Approval Number	30700AMX00269
Sales Begin	May 2026
Storage Instructions / Expiration Date	Store at room temperature / 2 years and 6 months
Insurance Benefits	–
Manufacturing and Sales Yuan	Santen Pharmaceutical Co., Ltd. 4-20 Ofuka-cho, Kita Ward, Osaka City
Packaging	Plastic Eye Drop Containers, 0.3 mL × 30 packs (1 aluminum foil pillow bag containing 10 books × 3 bags, including oxygen absorbers)
Shipping method	Direct overseas shipping (Direct shipping from Japan)
Preparation and shipping time	Once payment is confirmed, we typically ship the order within 4 to 7 business days.

1. Product hint

Conditions for Approval: A drug risk management plan must be developed and properly implemented.

Handling Instructions: After opening the aluminum foil pillow-shaped pouch, transfer the contents to the included light-protective dosing bag and store at room temperature; use within 3 months. If stored in the light-protective bag at 2–8°C, use within 1 year. Contains no preservatives; use only once after opening, and discard any remaining solution. Store in a light-protected area.

2. Product Characteristics and Mechanism of Action (18.)

Oxymetazoline acts on the alpha-adrenergic receptors of the Müller muscle, causing the Müller muscle to contract and thereby elevating the upper eyelid.

3. Specifications and Properties (3.2)

Colorless to pale yellow, clear, sterile aqueous eye drops. pH 6.0–6.7. Osmolarity ratio 1.0–1.2.

4. Ingredient Information (3.1/19.)

3.1　1 mg of oxymetazoline hydrochloride per 1 mL.

Additives: sodium chloride, potassium chloride, calcium chloride hydrate, magnesium chloride, sodium acetate hydrate, sodium citrate hydrate, hydroxypropyl methylcellulose, pH adjusters.

19. Chemical Name 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol monohydrochloride. Molecular formula C₁₆H₂₄N₂O·HCl. Molecular weight 296.84. White crystals or crystalline powder; odorless; bitter-tasting.

Structural Formula

5. Indications and Usage (4./5.)

4. acquired blepharoptosis

5.1 When the cause is deemed to be non-aponeurotic (e.g., stroke, cerebral aneurysm, Horner’s syndrome, myasthenia gravis, cutis laxa, etc.), treatment of the underlying condition should take priority.
5.2 Physicians must be thoroughly familiar with “17. Clinical Results” and select appropriate patients after fully understanding the trial’s inclusion criteria (MRD-1, disease subtype, etc.). MRD-1: The distance from the center of the pupil to the upper eyelid margin.
5.3 Periodically assess changes in eyelid position (MRD-1) and the patient’s chief complaint; discontinue treatment if ineffective.

6. Dosage and Administration (6./14.)

Adults should typically use 1 drop in each eye once daily.

14. Notes on Application

When opening the container, discard the first 1 to 2 drops—do not apply them to the eyes—to remove any container debris.
Do not allow the contents of the container to come into direct contact with your eyes.
Open the eyelid and insert the instrument into the conjunctival sac; keep the eyelid closed for 1 to 5 minutes while applying pressure to the lacrimal sac, then open the eyelid again.
Wait at least 5 minutes before using other eye drops.
Contains no preservatives. Use only once after opening; discard any remaining liquid.
Store away from light; keep out of reach of children.

7. Important Notes (8./9./10./11./13./20.)

8. The efficacy and safety of using these eye drops for more than 6 months have not been studied. Mydriasis may occur; avoid riding a bicycle, driving, or operating machinery until your pupils return to normal. Wear sunglasses when necessary to avoid looking directly into bright light. If you have eyelid inflammation (such as swelling or redness), wait until the symptoms subside before using this product.

9. Cardiovascular disorders: Fluctuations in blood pressure and pulse rate may worsen symptoms. Angle-closure glaucoma: May trigger an acute attack. Administer to pregnant women only if the benefits outweigh the risks. Use during breastfeeding requires careful consideration (oral administration in rats has been shown to result in transfer into breast milk). No clinical trials have been conducted in children.

10.2 Precautions for Concomitant Use　MAO inhibitors (selegiline, rasagiline, safinamide, etc.): May cause a sudden rise in blood pressure. Antihypertensive medications: The blood pressure-lowering effect may be enhanced. Cardiac glycosides (digoxin, etc.): The effect of increasing blood pressure or heart rate may be enhanced.

11.2 Itching of the eyelids (less than 1%). Frequency unknown: conjunctival hyperemia, punctate keratitis, blurred vision, conjunctival edema, eyelid eczema, visual disturbances; increased blood pressure, decreased heart rate.

13. Excess　Accidental ingestion may cause gastrointestinal, respiratory, cardiac, and consciousness disturbances. Overseas reports of accidental ingestion of imidazoline-containing eye drops by children include symptoms such as nausea, vomiting, drowsiness, tachycardia/bradycardia, decreased respiration, hypotension/hypertension, mydriasis, coma, and hypothermia.

20. After opening the aluminum foil packaging, place the product in a light-proof bag and use within 3 months at room temperature; if stored at 2–8°C, use within 1 year.

Domestic Phase III: Change from baseline in MRD-1 14 days after administration (2 hours after morning instillation): 1.09 ± 0.07 mm for the test drug and 0.50 ± 0.07 mm for the placebo; the between-group difference was 0.59 mm (p<0.0001). In the once-daily treatment group of 112 patients, 1 patient (0.91 TP3T) experienced eyelid itching.

Changes in MRD-1 Over Time

8. Contraindications (2.)

2.1 Patients with a history of allergy to any of the ingredients in this product.

21–26. Other Official Information

21. A drug risk management plan must be developed and implemented.

22. 0.3 mL × 30 vials (3 pouches of 10 vials each in aluminum foil pillow pouches, with desiccant)

24. Santai Pharmaceutical Co., Ltd. Product Information Center TEL 0120-921-839 / 06-7664-8624 (Weekdays 9:00 a.m.–5:00 p.m.)

25. This product is not covered by insurance (it is not included in the drug price reference list).

26. Manufacturer and Distributor: Santen Pharmaceutical Co., Ltd., 4-20 Ofuka-cho, Kita-ku, Osaka City

※ This page was translated by Hkeemall based on PMDA Package Insert 131970CQ1020_1_03 and is not a substitute for a doctor’s prescription or the original Japanese version.
Enter "Upneek Mini" in the PMDA "Package Insert Information" search field to view the original version.

[Disclaimer]

The information regarding medications, treatments, or health management contained in this article is compiled from international authoritative medical journals and official clinical literature, and is intended for general science and educational reference only.
The indications, side effects, and contraindications of related medications may vary depending on national regulations and individual physical conditions. Do not blindly take medication on your own or change your treatment plan.
The author and publishing platform assume no legal liability for any medical delays, adverse reactions, or direct or indirect losses caused by the use of the information in this article. All medical decisions should be discussed with your attending physician before being made.

Additional information

Specifications	Santen Upneek Mini 0.1%

1 review for 日本参天 UPNEEQ 美目莉阿普尼克鹽酸羥甲唑啉アップニークミニ点眼液 0.1% Mini ：30隻滴眼液眼藥水アップニーク点眼

5.00

Rated 5.00 out of 5 based on 1 customer rating

Average of 1 review

5 1

4 0

3 0

2 0

1 0

Rated 5 out of 5

SIU Queenie – August 28, 2026

After finishing, if you feel dazzled or your pupils are dilated, this is a normal reaction. Until the symptoms subside, remember not to drive, ride a bicycle, or operate dangerous machinery!

Add a review

Santen Japan UPNEEQ Meimuli Upneek Hydrochloride of Hydroxymethazoline Upneek Mini Eye Drops 0.1% Mini: 30 bottles Eye Drops Eye Medication Upneek Eye Drops

描述