(Due to limited stock, please contact customer service before placing an order.) Japan Calvan Bevantolol (Bevantolol Hydrochloride) Calvan Tablets 25mg, 50mg, 100mg: 100 tablets. Slows heart rate, dilates peripheral blood vessels, and steadily lowers blood pressure. Antihypertensive medication. Stabilizes heart rate.

2. Contraindications

1. Diabetic ketoacidosis, metabolic acidosis (which may contribute to decreased systolic contractility, peripheral arterial dilation, and decreased blood pressure)
2. Psychogenic Shock
3. Congestive Heart Failure
4. Right-sided heart failure caused by pulmonary hypertension
5. Severe bradycardia (marked sinus bradycardia), second- or third-degree atrioventricular block, sinoatrial block
6. Pregnant women or women who may be pregnant (reduced fetal body weight observed in rats) [9.5]
7. Untreated pheochromocytoma or paraganglioma [7.] [9.1.4]

8. Patients receiving long-term treatment should undergo regular cardiac function tests. Reduce the dose or discontinue the medication in cases of bradycardia or hypotension; administer atropine sulfate if necessary. Sudden discontinuation of similar medications has been associated with worsening angina or myocardial infarction; therefore, the medication must be tapered off gradually. Avoid administration within 48 hours prior to surgery. Dizziness may occur; avoid driving or operating hazardous machinery during the initial phase of treatment.

9. Patients at risk of heart failure should use this medication in combination with cardiac glycosides and with caution. Patients at risk of bronchial asthma or bronchospasm (this product also has β₂-blocking effects). Patients with idiopathic hypoglycemia, poorly controlled diabetes, or those who have fasted for an extended period are prone to hypoglycemia, which may mask symptoms such as tachycardia. For patients with severe renal or hepatic impairment, treatment should be initiated at a low dose. Weigh the benefits against the risks during breastfeeding (the drug is excreted in rat milk). No clinical trials have been conducted in children. Elderly patients should start with a low dose (e.g., 50 mg/day).

10.2 Precautions for Concomitant Use:Sympatholytic agents such as Lixiping (bradycardia, decreased blood pressure); hypoglycemic agents such as insulin and tolbutamide (enhanced hypoglycemia and masking of hypoglycemic symptoms); calcium channel blockers such as verapamil (excessive blood pressure reduction, cardiac function suppression); clonidine (may increase the risk of rebound hypertension upon discontinuation; this drug should be temporarily discontinued before stopping clonidine); antiarrhythmic drugs such as disopyramide, procainamide, and ajmaline (excessive cardiac function suppression).

11.1 Serious Adverse Effects:Heart failure (less than 0.11 TP3T), atrioventricular block (less than 11 TP3T), sinus node dysfunction (frequency unknown); asthma attacks, dyspnea (frequency unknown).

11.2:Neurological (dizziness, headache, drowsiness, insomnia, etc.), renal (elevated BUN/creatinine), hepatic (elevated ALT/AST), cardiovascular (bradycardia, palpitations, decreased blood pressure, etc.), respiratory (cough, shortness of breath, wheezing), gastrointestinal system, skin rash, urinary abnormalities, elevated uric acid/total cholesterol/CK/potassium, edema, fatigue, decreased tear production, etc.

13. Excess:Possible bradycardia, heart failure, bronchospasm, or hypoglycemia. Discontinue the medication and perform gastric lavage as needed. Treat bradycardia with atropine sulfate or, if necessary, isoproterenol or glucagon; treat hypotension with epinephrine; treat acute heart failure with cardiac glycosides, diuretics, and oxygen; treat bronchospasm with isoproterenol or theophylline; treat hypoglycemia with glucose.

14. PTP tablets must be removed from the blister pack before taking them; if swallowed accidentally, they may pierce the esophagus or even cause a perforation.