Name: Eisai Japan Methycobal Yikebo Methycobal Tablets, Methylcobalamin 500 μg: 100 tablets; Treatment for Peripheral Neuropathy
SKU: 3342
Price: 280 HKD
Availability: InStock

描述

Treatment for Peripheral Neuropathy | Methylcobalamin | Direct Shipping from Overseas (Direct from Japan)

Metikobal Tablets/Granules

Eisai, Mikabo, Methylcobalamin

Methycobal Tablets / Fine Granules

Package Insert No. 3136004C1038_1_05 | Company Code 170033
Prepared in April 2023 (1st Edition)

Tablets 250 μg, 500 μg | Granules 0.1%

Methycobal (Miko Bao) Methycobal Tablets, Methylcobalamin

Product Details / Approvals, etc.

Japan Standard Commodity Classification Code	873136
Pharmacological Classification Name	Therapeutic Agents for Peripheral Neuropathy
Generic Name / Standard Name	Methylcobalamin / Methylcobalamin Tablets
Tablet, 250 μg	YJ 3136004F1050 Approved 15400AMZ01326000 Sales began in June 1984 White sugar-coated tablet, 6.2 mm × 3.4 mm, 95 mg, identification number 321
Tablet, 500 μg	YJ 3136004F2138 Approved 15400AMZ01327000 Sales began in September 1981 White sugar-coated tablet 7.3 mm × 4.0 mm × 155 mg, identification number 322
Fine Grain 0.1%	YJ 3136004C1038 Approved 21900AMX00012000 Sales began in July 1984 Pink fine granules: 1,000 μg per 1 g
Storage Instructions / Expiration Date	Store at room temperature / 3 years
Manufacturing and Sales Yuan	Eisai Co., Ltd. 4-6-10 Koishikawa, Bunkyo Ward, Tokyo
Packaging	250 μg: PTP 100/1,000 tablets; bottle of 500 tablets 500 μg: PTP 100/210/1,000/1,050/3,000 tablets; bottle/aluminum pouch 500/3,000 tablets Fine granules: 60 g (0.5 g × 3 × 40)
Shipping method	Direct overseas shipping (Direct shipping from Japan)
Preparation and shipping time	Once payment is confirmed, we typically ship the order within 4 to 7 business days.

1. Composition and Physical and Chemical Properties (3/19)

Tablet: Each tablet contains 250 μg or 500 μg of mecobalamin. Granules: Each 1 g contains 1,000 μg (0.11 TP3T) and Red No. 102.

C₆₃H₉₁CoN₁₃O₁₄P Molecular weight 1344.38; dark red crystals or powder that decompose upon exposure to light.

Structural Formula

2. Mechanism of Action (18.)

The coenzyme form of vitamin B₁₂ in the body serves as a coenzyme for methionine synthase. It penetrates neural organelles more easily than cyanocobalamin, promoting nucleic acid and protein synthesis, axonal transport and regeneration, and myelination, while also improving delayed synaptic transmission and reducing acetylcholine deficiency.

3. Indications and Usage (4./6.)

Indications:Peripheral neuropathy.

The usual daily dose for adults is 1,500 μg of mecobalamin, taken orally in three divided doses; the dose may be adjusted based on age and symptoms.
250 μg tablets: 6 tablets per day | 500 μg tablets: 3 tablets per day | 0.1% granules: 3 packets per day (each packet contains 0.5 g = 500 μg).

4. Pharmacokinetics and Clinical Applications

Peak plasma levels are reached approximately 3 hours after a single oral dose. After 12 weeks of continuous treatment with 1,500 μg/day, total serum B₁₂ levels increased to approximately 2.8 times the pre-treatment level; 4 weeks after discontinuation, levels remained at approximately 1.8 times the pre-treatment level.

Single-Player PK
12 Weeks of Repetition

Chronic/Stable Peripheral Neuropathy, 4 weeks: 1,500 μg/day—“Improvement or better”: 17.61 TP3T; “Slight improvement or better”: 64.71 TP3T. In the control group treated with cobamamide and placebo, 38.61 TP3T (17/44) showed moderate improvement or better.

5. Precautions and Side Effects

Do not use continuously for several months if the treatment is ineffective. No clinical trials have been conducted in children. Workers who handle mercury and its compounds should not receive long-term, high-dose treatment.

Gastrointestinal (0.1–51 TP3T, not yet reached): Loss of appetite, nausea and vomiting, diarrhea. Allergic reactions (0.11 TP3T, not yet reached): Rash.

PTP tablets must be removed from the blister pack before use. PTP tablets, bottles, and aluminum pouches must be protected from light and moisture (exposure to light reduces potency; moisture may cause them to turn red). Do not remove fine granules from their individual packets for dispensing (exposure to light reduces potency).

22–26. Other Official Information

22. See the table above for packaging details.

24. Eisai Co., Ltd. hhc Hotline Toll-Free Number 0120-419-497

26. Manufacturer and Distributor: Eisai Co., Ltd., 4-6-10 Koishikawa, Bunkyo-ku, Tokyo

※ This page was translated by Hkeemall based on PMDA Package Insert 3136004C1038_1_05; it is not a substitute for a physician’s prescription or the original Japanese version.
Enter "Methycobal" in the PMDA "Package Insert Information" field to search for the original version.

[Disclaimer]

The information regarding medications, treatments, or health management contained in this article is compiled from international authoritative medical journals and official clinical literature, and is intended for general science and educational reference only.
The indications, side effects, and contraindications of related medications may vary depending on national regulations and individual physical conditions. Do not blindly take medication on your own or change your treatment plan.
The author and publishing platform assume no legal liability for any medical delays, adverse reactions, or direct or indirect losses caused by the use of the information in this article. All medical decisions should be discussed with your attending physician before being made.

Additional information

Specifications	Eisai Mikaho Methycobal Tablets 500 ug

1 review for 日本衛材 Methycobal 彌可保メチコバール錠甲鈷胺 500μg：100錠末梢性神經疾患治療劑

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Rated 5.00 out of 5 based on 1 customer rating

Average of 1 review

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1 0

Rated 5 out of 5

Vien Lee – August 27, 2026

Eating it made my legs feel much less numb, walking became a lot smoother, it really works.

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Eisai Japan Methycobal Yikebo Methycobal Tablets, Methylcobalamin 500 μg: 100 tablets; Treatment for Peripheral Neuropathy

描述

Metikobal Tablets/Granules

Eisai, Mikabo, Methylcobalamin

Methycobal Tablets / Fine Granules