Vonosap Pack 400 800 H. pylori Eradication Treatment Medication (1-Time Eradication) Takeda Japan One-Week H. pylori Eradication for Non-Smokers: 7 Tablets Takeda One-Week H. pylori Eradication

Helicobacter pylori eradication therapy medication (for primary eradication)

Chinese Translation:

Helicobacter pylori eradication therapy

This product is a combination of the following three preparations: Per blister pack (1 daily dose): Takecab Tablets 20 mg: 2 tablets Amolin Capsules 250: 6 capsules Clarith Tablets 200: 2 tablets Takecab Tablets 20 mg inhibit proton pumps in the gastric mucosa, suppressing gastric acid secretion and enhancing the antibacterial effects of the antibiotics (Clarith Tablets 200 and Amolin Capsules 250). Clarith Tablets 200 and Amolin Capsules 250 exhibit antibacterial activity against Helicobacter pylori. It is typically used for gastric ulcer, duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, Helicobacter pylori infection in the stomach after endoscopic treatment for early gastric cancer, and Helicobacter pylori-infected gastritis.

Chinese Translation:

This product is a combination of the following three preparations. In 1 sheet (1 day's supply): Takecab (Vonoprazan Fumarate) 20 mg tablets: 2 tablets Amolin (Amoxicillin) capsules 250: 6 capsules Clarith (Clarithromycin) 200 tablets: 2 tablets Vonoprazan fumarate 20 mg tablets inhibit the gastric mucosal proton pump, suppress gastric acid secretion, and enhance the antibacterial effects of the antibiotics (Clarithromycin 200 and Amoxicillin capsules 250). Clarithromycin 200 and Amoxicillin capsules 250 have antibacterial effects against Helicobacter pylori. It is typically used for gastric ulcer, duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, Helicobacter pylori infection after endoscopic treatment of early gastric cancer, and Helicobacter pylori-infected gastritis.

- Takecab Tablets 20mg Active ingredient in 1 tablet: 20mg as vonoprazan (26.72mg of vonoprazan fumarate) Additives: D-mannitol, crystalline cellulose, croscarmellose sodium, hydroxypropyl cellulose, fumaric acid, magnesium stearate, hypromellose, macrogol 6000, titanium dioxide, ferric oxide - Amolin Capsules 250 Active ingredient in 1 capsule: 250mg (potency) of amoxicillin hydrate Additives: magnesium stearate, methylcellulose, cornstarch, gelatin, sodium lauryl sulfate - Clarith Tablets 200 Active ingredient in 1 tablet: 200mg (potency) of clarithromycin Additives: sodium starch glycolate, cornstarch, hydroxypropyl cellulose, magnesium stearate, carnauba wax, paraffin, sucrose fatty acid esters, polysorbate 80, polyvinyl alcohol (partially saponified), hypromellose, titanium dioxide, light anhydrous silicic acid

Chinese Translation:

● Vonoprazan Fumarate Tablets 20mg Active ingredient in 1 tablet: Vonoprazan fumarate 20mg. Excipients: D-mannitol, crystalline cellulose, croscarmellose sodium, hydroxypropyl cellulose, fumaric acid, magnesium stearate, hypromellose, macrogol 6000, titanium oxide, ferric oxide ● Amoxicillin Capsules 250 Active ingredient in 1 capsule: Amoxicillin 250mg Excipients: Magnesium stearate, methylcellulose, corn starch, gelatin, sodium lauryl sulfate ● Clarithromycin 200 Active ingredient in 1 capsule: Clarithromycin 200mg Excipients: Sodium starch glycolate, corn starch, hydroxypropyl cellulose, magnesium stearate, carnauba wax, paraffin, sucrose fatty acid esters, polysorbate 80, polyvinyl alcohol (partially saponified)

Helicobacter pylori infection in the stomach after endoscopic treatment for gastric ulcer, duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, and early gastric cancer, and Helicobacter pylori-infected gastritis. For details, please check the external link and the package insert attached to the product.

Chinese Translation:

Helicobacter pylori infection of the stomach after endoscopic treatment for gastric ulcer, duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, or early gastric cancer; and Helicobacter pylori-infected gastritis. Please refer to the package insert for details.

Normally, for adults, the three drugs—vonoprazan at 20 mg, amoxicillin hydrate at 750 mg (potency), and clarithromycin at 200 mg (potency)—are orally administered simultaneously twice daily for 7 days. Clarithromycin may be increased as appropriate if necessary; however, the upper limit is 400 mg (potency) twice daily. Be sure to follow the prescribed dosage and administration instructions.

Chinese Translation:

Usually, adults take vonoprazan fumarate 20 mg (1 tablet), amoxicillin hydrate 750 mg (3 tablets), and clarithromycin 200 mg (1 tablet) simultaneously, twice a day. Take orally for 7 days. In addition, the dose of clarithromycin may be appropriately increased as needed. The upper limit is 400 mg (2 tablets) per dose, twice a day. Be sure to follow the doctor's instructions for administration.

Taking these medications may cause gastrointestinal symptoms such as diarrhea, taste abnormalities, or rashes. Please follow these instructions depending on your symptoms: 1) If you experience mild gastrointestinal symptoms such as loose stools or mild diarrhea, or taste abnormalities: Do not reduce the dose or frequency of the medication on your own; continue taking the remaining medication to the end (7 days). However, if your symptoms become severe, consult your attending doctor or pharmacist. 2) If you experience diarrhea accompanied by fever or abdominal pain, diarrhea containing mucus or blood, or a rash: Stop taking the medication immediately and contact your attending doctor or pharmacist. Other major side effects that have been reported include stomatitis, abdominal discomfort, abdominal fullness, itching, constipation, edema, fever, nausea, loss of appetite, vomiting, gastric discomfort, abdominal pain, hallucinations, disorientation (inability to recognize time, place, or name), impaired consciousness, delirium, mania, tremors, numbness, tinnitus, decreased hearing, olfactory abnormalities, oral erosions, tooth discoloration, muscle pain, candidiasis, palpitations, and hypoglycemia. If you notice any of these symptoms, consult your attending doctor or pharmacist. In rare cases, the following symptoms may appear, which could be early signs of the side effects indicated in brackets [ ]. In such cases, stop using the medication and seek medical attention immediately. Feeling unwell, sweating, difficulty breathing, rash, facial swelling, convulsions [shock, anaphylaxis] Generally feeling unwell, fever, shortness of breath, nosebleeds/subcutaneous bleeding, reddish-brown urine [thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, granulocytopenia] Yellowing of the skin or whites of the eyes, generally feeling unwell, loss of appetite [liver dysfunction, jaundice, liver failure, fulminant hepatitis] Fever, headache, joint pain, rash/redness on the skin, eyes, or mouth, skin tension/burning sensation/pain [toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, erythema multiforme, erythroderma] Fever, dry cough, difficulty breathing [PIE syndrome, interstitial pneumonia, eosinophilic pneumonia] Decreased urine output, swelling of the face and limbs, fever [acute kidney injury, tubulointerstitial nephritis] Abdominal pain, frequent diarrhea, bloody stool [pseudomembranous colitis, hemorrhagic colitis] Chest pain, palpitations, chest discomfort [QT prolongation, ventricular tachycardia (including Torsades de pointes), ventricular fibrillation] Weakness, muscle pain, brown urine [rhabdomyolysis] Convulsions [convulsions] Purpura [allergic purpura] Rash, fever [drug-induced hypersensitivity syndrome] Nuchal rigidity (stiff neck), fever, headache, nausea/vomiting [aseptic meningitis] These side effects do not represent a complete list. If you experience any other concerning symptoms, consult your doctor or pharmacist.

Chinese Translation:

Taking this medication may cause digestive symptoms such as diarrhea, taste abnormalities, or rashes. Please refer to the instructions below based on your symptoms. 1) If mild digestive symptoms such as loose stools or mild diarrhea, or taste abnormalities occur: Do not reduce the dosage or frequency on your own judgment. Finish the entire 7-day course of medication. However, if symptoms are severe, please consult a doctor. 2) If diarrhea accompanied by fever or abdominal pain occurs, if diarrhea contains mucus or blood, or if a rash appears: Stop taking the medication immediately and consult a doctor. Other major side effects include: stomatitis, abdominal discomfort, abdominal bloating, itching, constipation, edema, fever, nausea, loss of appetite, vomiting, gastric discomfort, abdominal pain, hallucinations, disorientation (confusion about time, place, or names), impaired consciousness, delirium, mania, tremors, numbness, tinnitus, hearing loss, olfactory disorders, oral erosions, tooth discoloration, muscle pain, candidiasis, palpitations, hypoglycemia, etc. If observed, please consult a doctor. Rarely, the following symptoms may occur, which could be early signs of the side effects listed in brackets [ ]. If observed, stop using the medication immediately and seek medical attention promptly: Feeling unwell, sweating, difficulty breathing, skin rash, facial swelling, convulsions [shock, anaphylaxis] General fatigue, fever, shortness of breath, nosebleeds/subcutaneous bleeding, reddish-brown urine [thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, granulocytopenia] Yellowing of the skin and whites of the eyes, dullness, loss of appetite [liver dysfunction, jaundice, liver failure, fulminant hepatitis] Fever, headache, joint pain, skin/eye/mouth rash/redness, skin tightness/burning sensation/pain [toxic epidermal necrolysis, mucocutaneous ocular syndrome, acute generalized exanthematous pustulosis, erythema multiforme, erythroderma] Fever, cough, suffocation [PIE syndrome, interstitial pneumonia, eosinophilic pneumonia] Decreased urine output, swelling of the face and limbs, fever [acute kidney injury, tubulointerstitial nephritis] Abdominal pain, frequent diarrhea, bloody stools [pseudomembranous colitis, hemorrhagic colitis] Chest pain, palpitations, chest discomfort [QT prolongation, ventricular tachycardia (including torsades de pointes), ventricular fibrillation] Weakness, muscle pain, brown urine [rhabdomyolysis] Convulsions [convulsions] Purpura [allergic purpura] Rash, fever [drug-induced hypersensitivity syndrome] Stiff neck, fever, headache, nausea/vomiting [aseptic meningitis] These are not all the possible side effects. If you notice any other symptoms, please consult a doctor.