{"id":3405,"date":"2026-04-09T08:02:18","date_gmt":"2026-04-09T08:02:18","guid":{"rendered":"https:\/\/hkeemall.com\/?post_type=product&#038;p=3405"},"modified":"2026-09-27T13:50:09","modified_gmt":"2026-09-27T05:50:09","slug":"1775721539","status":"publish","type":"product","link":"https:\/\/hkeemall.com\/en\/product\/1775721539\/","title":{"rendered":"Kowa (Japan) Parmodia (PemaBet) Parmodia Tablets 0.1 mg: 100 tablets\u2014Reduces triglyceride levels in non-familial hypertriglyceridemia"},"content":{"rendered":"<div class=\"mj-wrap\" style=\"max-width: 760px; margin: 0 auto; padding: 0 12px; color: #1c2328; font-family: 'PingFang TC','Hiragino Sans','Noto Sans TC','Microsoft JhengHei','Noto Sans JP',sans-serif; -webkit-font-smoothing: antialiased; line-height: 1.65; font-size: 15px; box-sizing: border-box;\">\n<style>\n@import url(\"https:\/\/fonts.googleapis.com\/css2?family=Noto+Sans+TC:wght@400;500;600;700&family=Noto+Serif+JP:wght@600;700&display=swap\");<br \/>.mj-wrap *,.mj-wrap *::before,.mj-wrap *::after{box-sizing:border-box}<br \/>.mj-wrap table{width:100%;border-collapse:collapse;font-size:13px;margin:10px 0}<br \/>.mj-wrap th,.mj-wrap td{border:1px solid #e4dfd6;padding:8px 10px;vertical-align:top;text-align:left;white-space:normal;overflow-wrap:anywhere;word-break:break-word}<br \/>.mj-wrap th{background:#f3efe8;color:#1c2328;font-weight:600}<br \/>.mj-wrap img{max-width:100%;height:auto}<br \/>.mj-wrap .mj-specs-wrap{overflow:visible}<br \/>@media (max-width:640px){<br \/>  .mj-sheet-inner{padding:20px 14px 16px !important}<br \/>  .mj-title{font-size:19px !important}<br \/>  .mj-h{font-size:16px !important}<br \/>  .mj-kicker{letter-spacing:.12em !important;font-size:10px !important}<br \/>  .mj-wrap .mj-specs,.mj-wrap .mj-specs tbody,.mj-wrap .mj-specs tr{display:block;width:100%}<br \/>  .mj-wrap .mj-specs th,.mj-wrap .mj-specs td{display:block;width:100%;max-width:100%}<br \/>  .mj-wrap .mj-specs th{padding:12px 12px 2px !important;background:transparent !important;border:0 !important;font-size:12px !important;color:#2c5a52 !important}<br \/>  .mj-wrap .mj-specs td{padding:2px 12px 12px !important;border:0 !important;border-bottom:1px solid #e4dfd6 !important;font-size:13px !important;line-height:1.7 !important}<br \/>  .mj-wrap .mj-specs tr:last-child td{border-bottom:0 !important}<br \/>}<br \/><\/style>\n<article class=\"mj-sheet\" style=\"background: #fbf9f5; border: 1px solid #e4dfd6; border-radius: 24px; overflow: hidden; box-shadow: 0 1px 0 rgba(28,35,40,.04),0 18px 40px -24px rgba(28,35,40,.18);\">\n<div class=\"mj-bar\" style=\"height: 4px; background: #2c5a52;\"><\/div>\n<div class=\"mj-sheet-inner\" style=\"padding: 32px 36px 28px;\">\n<div class=\"mj-kicker\" style=\"display: flex; align-items: center; justify-content: center; flex-wrap: wrap; gap: 8px; margin: 0 0 18px; color: #2c5a52; font-size: 11px; font-weight: 600; letter-spacing: .18em; text-align: center;\">Direct overseas shipping (Direct shipping from Japan)<\/div>\n<h2 class=\"mj-title\" style=\"font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 24px; font-weight: bold; line-height: 1.4; text-align: center; margin: 0 0 12px; color: #1c2328;\">PemaBet Palmodia Tablets 0.1 mg<br \/>\n<span style=\"font-size: 16px;\">PARMODIA\u00ae Tablets 0.1 mg<\/span><\/h2>\n<p class=\"mj-keys\" style=\"margin: 0 auto 10px; max-width: 620px; text-align: center; color: #3f4a46; font-size: 14px; font-weight: 600; line-height: 1.7;\">Package Insert No. 2183007F1025_1_14 | Company Code 270072<br \/>\nNovember 2023 (1st Edition) \/ Revised August 2024 (2nd Edition)<\/p>\n<p class=\"mj-keys\" style=\"margin: 0 auto 18px; max-width: 620px; text-align: center; color: #2c5a52; font-size: 14px; font-weight: 600; line-height: 1.7;\">Pemafibrate | Selective PPAR\u03b1 Modulator | Hyperlipidemia (including familial)<\/p>\n<figure class=\"mj-figure\" style=\"margin: 0 auto 24px; max-width: 100%; background: #fffcf8; border: 1px solid #e4dfd6; border-radius: 20px; padding: 12px; text-align: center;\"><a href=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/04\/7.webp\"><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-6986 size-full\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/04\/7.webp\" alt=\"PemaBet Palmodia Tablets 0.1 mg\" width=\"500\" height=\"500\" srcset=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/04\/7.webp 500w, https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/04\/7-300x300.webp 300w, https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/04\/7-150x150.webp 150w, https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/04\/7-12x12.webp 12w, https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/04\/7-450x450.webp 450w, https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/04\/7-54x54.webp 54w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><\/figure>\n<p style=\"font-size: 16px; font-weight: bold; color: #1c2328; margin: 0 0 12px; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif;\">Product Details \/ Approvals, etc.<\/p>\n<div class=\"mj-specs-wrap\" style=\"margin: 0 0 28px; border: 1px solid #e4dfd6; border-radius: 16px; background: #fffcf8;\">\n<table class=\"mj-specs\">\n<tbody>\n<tr>\n<th>Japan Standard Commodity Classification Code<\/th>\n<td>872183<\/td>\n<\/tr>\n<tr>\n<th>Pharmacological Classification Name<\/th>\n<td>Hyperlipidemia Treatment Agents<\/td>\n<\/tr>\n<tr>\n<th>General Name<\/th>\n<td>Pemafibrate<br \/>\nPemafibrate<\/td>\n<\/tr>\n<tr>\n<th>Specifications<\/th>\n<td>Parmodia Tablets 0.1 mg \/ PARMODIA TABLETS 0.1 mg<br \/>\nYJ 2183007F1025<br \/>\nApproved 22900AMX00581<br \/>\nOn Sale: June 2018<\/td>\n<\/tr>\n<tr>\n<th>Storage Instructions \/ Expiration Date<\/th>\n<td>Store at room temperature \/ 3 years<\/td>\n<\/tr>\n<tr>\n<th>Regulatory Classification<\/th>\n<td>\u2013<\/td>\n<\/tr>\n<tr>\n<th>Manufacturing and Sales Yuan<\/th>\n<td>Xinghe Co., Ltd.<br \/>\n4-14, Nihonbashi-Honcho 3-chome, Chuo Ward, Tokyo<\/td>\n<\/tr>\n<tr>\n<th>Packaging<\/th>\n<td>PTP 100\/500\/1,000 tablets; bulk bottle of 500 tablets<\/td>\n<\/tr>\n<tr>\n<th>Shipping method<\/th>\n<td>Direct overseas shipping (Direct shipping from Japan)<\/td>\n<\/tr>\n<tr>\n<th>Preparation and shipping time<\/th>\n<td>After verifying payment and prescription eligibility,<br \/>\nOrders are typically shipped within 4 to 7 business days.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">1. Conditions for Recognition<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<p style=\"margin: 0;\">A drug risk management plan must be developed and properly implemented.<\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">2. Composition and Properties (3.)<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<p style=\"margin: 0 0 8px;\">Each tablet contains 0.10 mg of pemafibrate. White, round, scored, film-coated tablets labeled \u201cPalmodia 0.1.\u201d Diameter: 7.1 mm; thickness: 2.9 mm; weight: 125 mg.<\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">3. Mechanism of Action (18.)<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<p style=\"margin: 0 0 8px;\">Pemafibrate binds to and selectively activates PPAR\u03b1, regulates target genes, reduces plasma TG, and increases HDL-C. It inhibits hepatic TG synthesis and secretion, increases LPL activity, reduces ApoC-III\/ANGPTL3, promotes fatty acid \u03b2-oxidation and TG clearance, and increases FGF21.<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/09\/270072_2183007F1025_1_14_fig03.gif\" alt=\"Structural Formula\" \/><\/p>\n<p style=\"margin: 8px 0 0;\">C<sub>28<\/sub>H<sub>30<\/sub>N<sub>2<\/sub>O<sub>6<\/sub>\u3000Molecular weight: 490.55; Melting point: 95\u2013101\u00b0C<\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">4. Indications and Dosage (4.\u20137.)<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<p style=\"margin: 0 0 8px;\"><strong>Indications:<\/strong>Hyperlipidemia (including familial hyperlipidemia). This product is not the first-line treatment for patients with elevated LDL-C alone. A thorough evaluation and confirmed diagnosis are required prior to use.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong>Directions:<\/strong>The usual adult dose of pemafibrate is 0.1 mg twice daily, taken orally in the morning and evening. The dose may be adjusted based on age and symptoms, up to a maximum of 0.2 mg twice daily.<\/p>\n<p style=\"margin: 0;\">When eGFR is &lt;30 mL\/min\/1.73 m\u00b2, start with a low dose, reduce the dose, or extend the dosing interval; the maximum daily dose is 0.2 mg.<\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h mj-h-alert\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #7a2e2e; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #7a2e2e;\">5. Contraindications and Precautions (2.\/8.\/9.\/10.)<\/h3>\n<div class=\"mj-panel mj-panel-alert\" style=\"background: #f7efe9; border: 1px solid #e4cfc6; border-radius: 14px; padding: 16px 18px; color: #6b3a34; font-size: 14px; line-height: 1.8;\">\n<ol style=\"margin: 0 0 12px; padding-left: 20px;\">\n<li>Allergy to any ingredient in this product<\/li>\n<li>Severe hepatic impairment, Child-Pugh Class B\/C cirrhosis, or biliary obstruction<\/li>\n<li>Gallstones<\/li>\n<li>Pregnant women or women who may be pregnant<\/li>\n<li>Currently taking cyclosporine and rifampicin<\/li>\n<\/ol>\n<p style=\"margin: 0 0 8px;\">Begin with dietary therapy, and consider exercise and risk factors for ischemic heart disease. Check blood lipid levels regularly; if treatment is ineffective, do not continue it indiscriminately. Perform regular liver function tests. LDL-C levels may rise during treatment, so regular monitoring is required.<\/p>\n<p style=\"margin: 0 0 8px;\">In patients with impaired renal function, HMG-CoA reductase inhibitors should be used in combination only when clinically necessary; if myalgia, weakness, or elevated CK, myoglobin, or creatinine levels occur, the medication must be discontinued immediately. Use is not recommended during breastfeeding. No clinical trials have been conducted in children. Use with caution in the elderly.<\/p>\n<p style=\"margin: 0 0 8px;\">It is primarily metabolized by CYP2C8, 2C9, and 3A, and is a substrate for OATP1B1 and 1B3. Concomitant use precautions: statins, clopidogrel, etc. (See the original version for details.)<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/09\/270072_2183007F1025_1_14_fig02.gif\" alt=\"PK\" \/><\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">6. Clinical Summary<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<p style=\"margin: 0;\">International Trial on Dyslipidemia in Type 2 Diabetes (n=10,497, median follow-up 3.32 years): HR for the primary cardiovascular composite endpoint with this drug versus placebo was 1.03 [0.92\u20131.16]. The difference in the rate of change in fasting triglycerides (TG) over 4 months was approximately \u221224.41 TP3T. Major adverse events included elevated CK levels and myalgia. The incidence of pulmonary embolism\/deep vein thrombosis was higher in the treatment group, but a causal relationship with the drug was ruled out in all cases.<\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">20\u201326. Other Official Information<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">20.<\/strong> Keep away from moisture after opening. Store in a dry place at room temperature after cutting, and use within 4 months.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">22.<\/strong> PTP 100\/500\/1,000 tablets; bulk bottle of 500 tablets<\/p>\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">24.<\/strong> Kohwa Co., Ltd. Medication Consultation Center Phone: 0120-508-514 \/ 03-3279-7587 (9:00 a.m.\u20135:00 p.m.)<\/p>\n<p style=\"margin: 0;\"><strong style=\"color: #1c2328;\">26.<\/strong> Manufacturer and Distributor: Kowa Co., Ltd., 4-14 Nihonbashi-Honcho 3-chome, Chuo-ku, Tokyo<\/p>\n<\/div>\n<\/section>\n<div class=\"mj-foot\" style=\"margin: 8px 0 0; padding: 18px 8px 4px; border-top: 1px solid #e4dfd6; text-align: center; color: #7a2e2e; font-size: 13px; line-height: 1.7;\">\u203b This page was translated by Hkeemall based on PMDA Package Insert 2183007F1025_1_14; it is not a substitute for a doctor\u2019s prescription or the original Japanese version.<br \/>\n<a style=\"color: #7a2e2e; font-weight: bold; text-decoration: underline;\" href=\"https:\/\/www.pmda.go.jp\/PmdaSearch\/iyakuDetail\/270072_2183007F1025_1_14#HDR_ContraIndications\" target=\"_blank\" rel=\"noreferrer noopener\">Enter \"Palmodia\" in the PMDA \"Package Insert Information\" search field to view the original version.<\/a><\/div>\n<\/div>\n<\/article>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u6d77\u5916\u76f4\u90f5\uff08\u65e5\u672c\u76f4\u90f5\uff09 \u4f69\u746a\u8c9d\u7279 \u30d1\u30eb\u30e2\u30c7\u30a3\u30a2\u93200.1mg PARMODIA\u00ae Tablets 0.1mg \u6dfb\u4ed8<\/p>\n<div class=\"klb-readmore post-buttons\"><a class=\"button rounded primary\" href=\"https:\/\/hkeemall.com\/en\/product\/1775721539\/\">Read More <i class=\"klbth-icon-right-arrow\"><\/i><\/a><\/div>","protected":false},"featured_media":6986,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[246],"product_cat":[23,69],"product_tag":[245],"class_list":["post-3405","product","type-product","status-publish","has-post-thumbnail","product_brand-kowa","product_cat-allergies","product_cat-69","product_tag-kowa","first","instock","featured","shipping-taxable","purchasable","product-type-variable","has-default-attributes"],"_links":{"self":[{"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/product\/3405","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/comments?post=3405"}],"version-history":[{"count":14,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/product\/3405\/revisions"}],"predecessor-version":[{"id":8203,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/product\/3405\/revisions\/8203"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/media\/6986"}],"wp:attachment":[{"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/media?parent=3405"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/product_brand?post=3405"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/product_cat?post=3405"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/product_tag?post=3405"}],"curies":[{"name":"Well played","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}