{"id":5167,"date":"2026-08-22T02:42:32","date_gmt":"2026-08-22T02:42:32","guid":{"rendered":"https:\/\/hkeemall.com\/?p=5167"},"modified":"2026-10-02T13:40:12","modified_gmt":"2026-10-02T05:40:12","slug":"1787813600-2","status":"publish","type":"post","link":"https:\/\/hkeemall.com\/en\/1787813600-2\/","title":{"rendered":"Japanese Version \"Mounjaro Mounjaro Weight Loss Pen Tirzepatide Diet Pen Tirzepatide\" Instructions-Price-Indications-Side Effects and Precautions"},"content":{"rendered":"<div class=\"mj-wrap\" style=\"max-width: 760px; margin: 0 auto; padding: 0 12px; color: #1c2328; font-family: 'PingFang TC','Hiragino Sans','Noto Sans TC','Microsoft JhengHei','Noto Sans JP',sans-serif; -webkit-font-smoothing: antialiased; line-height: 1.65; font-size: 15px; box-sizing: border-box; overflow-x: hidden; width: 100%;\">\n<style>\n@import url(\"https:\/\/fonts.googleapis.com\/css2?family=Noto+Sans+TC:wght@400;500;600;700&family=Noto+Serif+JP:wght@600;700&display=swap\");<br \/>.mj-wrap,.mj-wrap *{box-sizing:border-box;max-width:100%}<br \/>.mj-wrap *,.mj-wrap *::before,.mj-wrap *::after{box-sizing:border-box}<br \/>.mj-title,.mj-keys,.mj-panel,.mj-wrap p,.mj-wrap li,.mj-wrap td,.mj-wrap th{overflow-wrap:anywhere;word-break:break-word}<br \/>.mj-wrap img{max-width:100%;height:auto;display:block}<br \/>.mj-wrap video{max-width:100%;height:auto;display:block;background:#111}<br \/>.mj-wrap table{width:100%;max-width:100%;border-collapse:collapse;font-size:13px;margin:10px 0;table-layout:fixed}<br \/>.mj-wrap th,.mj-wrap td{border:1px solid #e4dfd6;padding:8px 10px;vertical-align:top;text-align:left;white-space:normal;overflow-wrap:anywhere;word-break:break-word}<br \/>.mj-wrap th{background:#f3efe8;color:#1c2328;font-weight:600}<br \/>.mj-pics{display:flex;flex-wrap:wrap;gap:8px;align-items:flex-start}<br \/>.mj-pics img{width:calc(50% - 4px);max-width:220px;height:auto;background:#fff}<br \/>@media (max-width:640px){<br \/>.mj-sheet-inner{padding:20px 14px 16px !important}<br \/>.mj-title{font-size:19px !important}<br \/>.mj-h{font-size:16px !important}<br \/>.mj-kicker{letter-spacing:.12em !important;font-size:10px !important}<br \/>.mj-wrap table,.mj-wrap thead,.mj-wrap tbody,.mj-wrap tr,.mj-wrap .mj-specs,.mj-wrap .mj-specs tbody,.mj-wrap .mj-specs tr{display:block;width:100%;max-width:100%}<br \/>.mj-wrap th,.mj-wrap td,.mj-wrap .mj-specs th,.mj-wrap .mj-specs td{display:block;width:100%;max-width:100%;border-left:0;border-right:0}<br \/>.mj-wrap thead{display:none}<br \/>.mj-wrap .mj-specs th,.mj-wrap table th{padding:12px 12px 2px !important;background:transparent !important;border:0 !important;font-size:12px !important;color:#2c5a52 !important}<br \/>.mj-wrap .mj-specs td,.mj-wrap table td{padding:2px 12px 12px !important;border:0 !important;border-bottom:1px solid #e4dfd6 !important;font-size:13px !important;line-height:1.7 !important}<br \/>.mj-wrap .mj-specs tr:last-child td,.mj-wrap table tr:last-child td{border-bottom:0 !important}<br \/>.mj-pics img{width:calc(50% - 4px);max-width:none}<br \/>}<br \/><\/style>\n<article class=\"mj-sheet\" style=\"background: #fbf9f5; border: 1px solid #e4dfd6; border-radius: 24px; overflow: hidden; box-shadow: 0 1px 0 rgba(28,35,40,.04),0 18px 40px -24px rgba(28,35,40,.18); width: 100%;\">\n<div class=\"mj-bar\" style=\"height: 4px; background: #2c5a52;\"><\/div>\n<div class=\"mj-sheet-inner\" style=\"padding: 32px 36px 28px;\">\n<div class=\"mj-kicker\" style=\"display: flex; align-items: center; justify-content: center; flex-wrap: wrap; gap: 8px; margin: 0 0 18px; color: #2c5a52; font-size: 11px; font-weight: 600; letter-spacing: .18em; text-align: center;\">Direct Shipping from Overseas | GIP\/GLP-1<\/div>\n<h2 class=\"mj-title\" style=\"font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 24px; font-weight: bold; line-height: 1.4; text-align: center; margin: 0 0 12px; color: #1c2328;\">Mounjaro Telporotide Injection<br \/>\n<span style=\"font-size: 16px;\">Mounjaro\u00ae (Tirzepatide)<\/span><br \/>\n<span style=\"font-size: 15px; font-weight: 600;\">2.5 mg \/ 5 mg \/ 7.5 mg \/ 10 mg \/ 12.5 mg \/ 15 mg<\/span><\/h2>\n<p class=\"mj-keys\" style=\"margin: 0 auto 18px; max-width: 620px; text-align: center; color: #2c5a52; font-size: 14px; font-weight: 600; line-height: 1.7;\">Eli Lilly | Once-weekly dual GIP\/GLP-1 receptor agonist | Adjuvant therapy for type 2 diabetes<\/p>\n<figure class=\"mj-figure\" style=\"margin: 0 auto 24px; max-width: 100%; background: #fffcf8; border: 1px solid #e4dfd6; border-radius: 20px; padding: 12px;\"><a href=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/1-21.webp\"><img decoding=\"async\" style=\"width: 100%; height: auto; display: block; margin: 0 auto;\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/1-21.webp\" alt=\"Mounjaro Telporodate\" \/><\/a><\/figure>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8; margin: 0 0 22px;\">\n<p style=\"margin: 0 0 8px;\">On May 13, 2022, the U.S. Food and Drug Administration (FDA) approved Eli Lilly\u2019s once-weekly dual GIP and GLP-1 receptor agonist Mounjaro (Tirzepatide \/ tirzepatide), as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.<\/p>\n<p style=\"margin: 0;\">This is the first-of-its-kind once-weekly dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, and the first new class of antidiabetic drug to be approved for marketing in the past decade. Mounjaro combines the actions of two gut-derived insulin-secreting peptides into a single molecule, enhancing both first- and second-phase insulin secretion in a glucose-dependent manner while reducing glucagon levels.<\/p>\n<\/div>\n<h2><a href=\"https:\/\/hkeemall.com\/product\/1787813877\/\">\u27a1\ufe0f Click to view product details and specifications<\/a><\/h2>\n<p style=\"font-size: 16px; font-weight: bold; color: #1c2328; margin: 0 0 12px; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif;\">How-to Videos<\/p>\n<div style=\"margin: 0 0 22px; border: 1px solid #e4dfd6; border-radius: 16px; overflow: hidden; background: #111;\">\n<div style=\"width: 720px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-5167-1\" width=\"720\" height=\"720\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/\u65e5\u7248\u66ff\u897f\u9a8c\u8bc1\u65b9\u5f0f\u53ca\u4f7f\u7528\u8bf4\u660e.mp4?_=1\" \/><a href=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/\u65e5\u7248\u66ff\u897f\u9a8c\u8bc1\u65b9\u5f0f\u53ca\u4f7f\u7528\u8bf4\u660e.mp4\">https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/\u65e5\u7248\u66ff\u897f\u9a8c\u8bc1\u65b9\u5f0f\u53ca\u4f7f\u7528\u8bf4\u660e.mp4<\/a><\/video><\/div>\n<\/div>\n<p style=\"font-size: 16px; font-weight: bold; color: #1c2328; margin: 0 0 12px; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif;\">Product Details<\/p>\n<div class=\"mj-specs-wrap\" style=\"margin: 0 0 28px; border: 1px solid #e4dfd6; border-radius: 16px; background: #fffcf8; overflow: hidden;\">\n<table class=\"mj-specs\">\n<tbody>\n<tr>\n<th>manufacturing enterprise<\/th>\n<td>Eli Lilly<\/td>\n<\/tr>\n<tr>\n<th>Trademark<\/th>\n<td>Mounjaro<\/td>\n<\/tr>\n<tr>\n<th>Generic Name<\/th>\n<td>Tirzepatide, Tirzepatide, Tirzepatide<\/td>\n<\/tr>\n<tr>\n<th>Specifications<\/th>\n<td>0.5 mL single-dose pen<br \/>\n2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg<\/td>\n<\/tr>\n<tr>\n<th>Storage<\/th>\n<td>1. Store in the refrigerator at 2\u00b0C to 8\u00b0C.<br \/>\n2. If necessary, each single-dose pen may be stored at a temperature not exceeding 37\u00b0C without refrigeration for up to 21 days.<br \/>\n3. Do not freeze. If frozen, do not use.<br \/>\n4. Store in the original carton and keep away from light.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">Indication<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<ol style=\"margin: 0; padding-left: 20px;\">\n<li style=\"margin-bottom: 6px;\">As an adjunct to diet and exercise, it is used to improve blood glucose control in adults with type 2 diabetes.<\/li>\n<li>Restrictions on Use: No studies have been conducted in patients with a history of pancreatitis; not indicated for patients with type 1 diabetes.<\/li>\n<\/ol>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">Recommended Dosage<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<ol style=\"margin: 0; padding-left: 20px;\">\n<li style=\"margin-bottom: 6px;\">The recommended starting dose is 2.5 mg administered once weekly by subcutaneous injection. The 2.5 mg dose is used to initiate treatment and is not intended for blood glucose control.<\/li>\n<li style=\"margin-bottom: 6px;\">After 4 weeks, increase the dose to 5 mg, administered once weekly by subcutaneous injection.<\/li>\n<li style=\"margin-bottom: 6px;\">If additional blood glucose control is needed, increase the dose in 2.5 mg increments after at least 4 weeks on the current dose.<\/li>\n<li style=\"margin-bottom: 6px;\">The maximum dose is 15 mg, administered once weekly by subcutaneous injection.<\/li>\n<li style=\"margin-bottom: 6px;\">If you miss a dose, take it as soon as possible within 4 days (96 hours) of missing it. If more than 4 days have passed, skip the missed dose, take the next dose on the regularly scheduled date, and then resume your regular once-weekly dosing schedule.<\/li>\n<li>If necessary, the weekly dosing schedule may be adjusted, provided that there is an interval of at least 3 days (72 hours) between doses.<\/li>\n<\/ol>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">Instructions for Use<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<p style=\"margin: 0 0 8px;\"><a href=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/1-14.webp\"><img decoding=\"async\" style=\"max-width: 160px; height: auto;\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/1-14.webp\" alt=\"Insulin Pen\" \/><\/a><\/p>\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">Preparing for the injection<\/strong><\/p>\n<ol style=\"margin: 0 0 12px; padding-left: 20px;\">\n<li>Remove the insulin pen from the refrigerator.<\/li>\n<li>Do not remove the gray base cap before preparing for the injection.<\/li>\n<li>Check the label on the pen to make sure the medication and dosage are correct and that it has not expired.<\/li>\n<li>Check that the pen is not damaged.<\/li>\n<li>Inspection of the medication: Not frozen, not cloudy, colorless to slightly yellow, and free of particles.<\/li>\n<li>Wash your hands.<\/li>\n<\/ol>\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">Step 1: Choose an injection site<\/strong><br \/>\nYour doctor can help you choose the most appropriate injection site. You can inject into your abdomen or thigh, or have someone else inject you in the back of your upper arm. Rotate your injection sites weekly. You can inject into the same area, but be sure to choose a different spot within that area each time.<\/p>\n<div class=\"mj-pics\"><a href=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/2-6.webp\"><img decoding=\"async\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/2-6.webp\" alt=\"Injection Site 1\" \/><\/a><br \/>\n<a href=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/3-4.webp\"><img decoding=\"async\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/3-4.webp\" alt=\"Injection Site 2\" \/><\/a><\/div>\n<p style=\"margin: 12px 0 8px;\"><strong style=\"color: #1c2328;\">Step 2: Pull down the gray base<\/strong><br \/>\nMake sure the pen is locked. Do not unlock the pen until you have applied the clear base to your skin and are ready to inject. Pull the gray cap off and throw it in the trash. Do not put the gray cap back on, as this may damage the needle. Do not touch the needle.<\/p>\n<p><a href=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/4-4.webp\"><img decoding=\"async\" style=\"max-width: 220px; height: auto;\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/4-4.webp\" alt=\"Pull down the gray base\" \/><\/a><\/p>\n<p style=\"margin: 12px 0 8px;\"><strong style=\"color: #1c2328;\">Step 3: Attach the transparent base to your skin, then unlock it.<\/strong><br \/>\nPlace the transparent base flat against the skin at the injection site, and turn the locking ring to unlock it.<\/p>\n<div class=\"mj-pics\"><a href=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/5-3.webp\"><img decoding=\"async\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/5-3.webp\" alt=\"Attach the base\" \/><\/a><br \/>\n<a href=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/6-3.webp\"><img decoding=\"async\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/6-3.webp\" alt=\"Unlock\" \/><\/a><\/div>\n<p style=\"margin: 12px 0 8px;\"><strong style=\"color: #1c2328;\">Step 4: Press and hold for 10 seconds<\/strong><br \/>\nPress and hold the purple injection button for 10 seconds. Listen for the sounds: the first beep indicates the start of the injection, and the second beep indicates the end of the injection. When the gray plunger becomes visible, the injection is complete. After the injection, place the used pen in a sharps container.<\/p>\n<div class=\"mj-pics\"><a href=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/7-3.webp\"><img decoding=\"async\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/7-3.webp\" alt=\"Press and hold the button\" \/><\/a><br \/>\n<a href=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/8-3.webp\"><img decoding=\"async\" src=\"https:\/\/hkeemall.com\/wp-content\/uploads\/2026\/08\/8-3.webp\" alt=\"Injection Complete\" \/><\/a><\/div>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">Frequently Asked Questions<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<ol style=\"margin: 0; padding-left: 20px;\">\n<li style=\"margin-bottom: 6px;\">What should I do if I see bubbles in the pen? It's normal to have bubbles.<\/li>\n<li style=\"margin-bottom: 6px;\">What should I do if my pen isn't at room temperature? There's no need to warm the pen up to room temperature.<\/li>\n<li style=\"margin-bottom: 6px;\">What happens if I unlock the pen first, then press the purple injection button, and then remove the gray cap? Do not remove the gray cap. Discard the pen and replace it with a new one.<\/li>\n<li style=\"margin-bottom: 6px;\">What should I do if there is a drop of liquid on the needle tip when I remove the gray cap? It is normal for there to be a drop of liquid on the needle tip. Do not touch the needle.<\/li>\n<li style=\"margin-bottom: 6px;\">Do I need to hold down the injection button until the injection is complete? It's not necessary, but it can help you keep the pen steady.<\/li>\n<li style=\"margin-bottom: 6px;\">During the injection, I heard more than two clicks\u2014two loud clicks and one soft click. Is the injection finished? Some people may hear a soft click before the second loud click. That\u2019s normal; do not remove the pen from your skin until you hear the second loud click.<\/li>\n<li style=\"margin-bottom: 6px;\">I'm not sure if my pen is working properly. Check to see if you received the injection. If the gray plunger is visible, it means the dose was delivered correctly.<\/li>\n<li>What should I do if there's a drop of fluid or blood on my skin after the injection? This is normal. Press a cotton ball or gauze against the injection site. Do not rub the injection site.<\/li>\n<\/ol>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">Precautions and Overdose<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<ol style=\"margin: 0 0 8px; padding-left: 20px;\">\n<li>Take Mounjaro once a week, at any time of day, with or without food.<\/li>\n<li>Administer Mounjaro by subcutaneous injection in the abdomen, thigh, or upper arm.<\/li>\n<li>Rotate injection sites with each injection.<\/li>\n<li>Visually inspect Mounjaro before injection; it should be clear, colorless to slightly yellow. Do not use if you notice any particulate matter or discoloration.<\/li>\n<li>When using Mounjaro with insulin, administer them as separate injections; do not mix them. It is acceptable to inject into the same area of the body, but do not inject too close to the same spot.<\/li>\n<\/ol>\n<p style=\"margin: 0;\">In the event of an overdose, contact a poison control center for the most up-to-date management recommendations. Initiate appropriate supportive care based on the patient\u2019s clinical symptoms and signs. Given that the half-life of tirzepatide is approximately 5 days, observation and treatment of these symptoms may be required for some time.<\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h mj-h-alert\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #7a2e2e; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #7a2e2e;\">Warnings and Precautions<\/h3>\n<div class=\"mj-panel mj-panel-alert\" style=\"background: #f7efe9; border: 1px solid #e4cfc6; border-radius: 14px; padding: 16px 18px; color: #6b3a34; font-size: 14px; line-height: 1.8;\">\n<p style=\"margin: 0 0 8px;\"><strong>1. Risk of Thyroid C-Cell Tumors<\/strong><br \/>\nIn a 2-year clinically relevant plasma exposure study, the incidence of thyroid C-cell tumors (adenomas and carcinomas) in male and female rats increased in a dose-dependent and treatment-duration-dependent manner. It is unknown whether Mounjaro causes thyroid C-cell tumors in humans, including medullary thyroid carcinoma (MTC), as the relevance of tirzepatide-induced thyroid C-cell tumors in rodents to humans has not been established. This drug is contraindicated in patients with a personal or family history of MTC or in patients with multiple endocrine neoplasia type 2 (MEN 2). Inform patients of the potential risk of MTC and the symptoms of thyroid tumors (e.g., neck lump, difficulty swallowing, shortness of breath, persistent hoarseness). The value of routine monitoring of serum calcitonin or thyroid ultrasound for the early detection of MTC in patients receiving Mounjaro is uncertain. Such monitoring may increase the risk of unnecessary procedures, as serum calcitonin testing has low specificity and a high prevalence of underlying thyroid disease. A significantly elevated serum calcitonin level may suggest MTC; calcitonin levels in MTC patients are typically &gt; 50 ng\/L. If an elevation is detected, further evaluation is warranted; patients with thyroid nodules identified on physical examination or neck imaging should also undergo further evaluation.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong>2. Pancreatitis<\/strong><br \/>\nAcute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists. In clinical studies, 14 cases of acute pancreatitis were confirmed in 13 patients treated with Mounjaro, compared with 3 cases in 3 patients receiving control therapy. No studies have been conducted in patients with a history of pancreatitis. It is unknown whether patients with a history of pancreatitis are at increased risk of pancreatitis when using Mounjaro. After initiating treatment, carefully monitor for symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back, with or without vomiting). If pancreatitis is suspected, discontinue Mounjaro and initiate appropriate treatment.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong>3. Hypoglycemia associated with the use of insulin secretagogues or insulin<\/strong><br \/>\nPatients receiving Mounjaro in combination with insulin secretagogues (such as sulfonylureas) or insulin may be at increased risk of hypoglycemia, including severe hypoglycemia. Reducing the dose of sulfonylureas (or other concomitantly administered insulin secretagogues) or insulin can lower the risk of hypoglycemia. Inform patients using these combination therapies about the risk of hypoglycemia and the signs and symptoms of hypoglycemia.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong>4. Allergic Reactions<\/strong><br \/>\nAllergic reactions (such as urticaria and eczema) have been reported in clinical trials. If an allergic reaction occurs, discontinue use, provide prompt treatment, and monitor the patient until symptoms and signs resolve. Do not use in patients with a history of severe allergic reactions to tirzepatide or any of the excipients in Mounjaro. Allergic reactions and angioedema have been reported with GLP-1 receptor agonists. Use with caution in patients with a history of angioedema or allergy to GLP-1 receptor agonists, as it is unknown whether such patients are at increased risk of an allergic reaction to Mounjaro.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong>5. Acute Kidney Injury<\/strong><br \/>\nMounjaro is associated with gastrointestinal adverse reactions, including nausea, vomiting, and diarrhea. These events may lead to dehydration and, in severe cases, may result in acute kidney injury. There have been postmarketing reports of acute kidney injury and worsening chronic kidney disease in patients treated with GLP-1 receptor agonists, sometimes requiring hemodialysis. Some of these events occurred in patients with no known underlying kidney disease. Most reports occurred in patients experiencing nausea, vomiting, diarrhea, or dehydration. Monitor renal function when initiating treatment or increasing the dose in patients with impaired renal function who have reported severe gastrointestinal adverse reactions.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong>6. Severe gastrointestinal diseases<\/strong><br \/>\nThe use of Mounjaro has been associated with gastrointestinal adverse reactions, which can sometimes be severe. No studies have been conducted in patients with severe gastrointestinal diseases (including severe gastroparesis); therefore, its use is not recommended in these patients.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong>7. Complications in Patients with a History of Diabetic Retinopathy<\/strong><br \/>\nRapid improvements in blood glucose control have been associated with a temporary worsening of diabetic retinopathy. No studies have been conducted in patients with nonproliferative diabetic retinopathy, proliferative diabetic retinopathy, or diabetic macular edema requiring acute treatment. Patients with a history of diabetic retinopathy should be monitored for progression.<\/p>\n<p style=\"margin: 0;\"><strong>8. Acute Cholecystitis<\/strong><br \/>\nAcute episodes of gallbladder disease, such as cholelithiasis or cholecystitis, have been reported in clinical trials and postmarketing reports of GLP-1 receptor agonists. In placebo-controlled clinical trials, 0.6% of patients treated with Mounjaro and 0% of patients treated with placebo reported acute gallbladder disease (gallstones, biliary colic, and cholecystectomy). If gallstones are suspected, diagnostic gallbladder studies and appropriate clinical follow-up are required.<\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h mj-h-alert\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #7a2e2e; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #7a2e2e;\">Contraindications<\/h3>\n<div class=\"mj-panel mj-panel-alert\" style=\"background: #f7efe9; border: 1px solid #e4cfc6; border-radius: 14px; padding: 16px 18px; color: #6b3a34; font-size: 14px; line-height: 1.8;\">\n<ol style=\"margin: 0; padding-left: 20px;\">\n<li>Patients with a personal or family history of medullary thyroid carcinoma (MTC) or those with multiple endocrine neoplasia type 2 (MEN 2).<\/li>\n<li>Known severe allergy to tirzepatide or any of the excipients in Mounjaro.<\/li>\n<\/ol>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">Drug Interactions<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">Insulin-releasing hormone or insulin<\/strong><br \/>\nWhen you start taking Mounjaro, consider reducing the dose of any concomitant insulin secretagogues (such as sulfonylureas) or insulin to lower the risk of hypoglycemia.<\/p>\n<p style=\"margin: 0;\">Mounjaro delays gastric emptying and may therefore affect the absorption of oral medications taken at the same time. Caution is advised when oral medications are taken concomitantly with Mounjaro. Particular caution is warranted for patients whose oral medications are monitored based on therapeutic threshold concentrations, as well as for patients receiving concomitant medications with a narrow therapeutic index (e.g., warfarin). Patients using oral hormonal contraceptives are advised to switch to a non-oral method of contraception or to add a barrier method 4 weeks after initiation and 4 weeks after each dose increase. Non-oral hormonal contraceptives are not expected to be affected.<\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h mj-h-alert\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #7a2e2e; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #7a2e2e;\">adverse reaction<\/h3>\n<div class=\"mj-panel mj-panel-alert\" style=\"background: #f7efe9; border: 1px solid #e4cfc6; border-radius: 14px; padding: 16px 18px; color: #6b3a34; font-size: 14px; line-height: 1.8;\">\n<ol style=\"margin: 0 0 8px; padding-left: 20px;\">\n<li style=\"margin-bottom: 6px;\">Possible thyroid tumors, including cancer. If you notice a lump or swelling in your neck, hoarseness, difficulty swallowing, or shortness of breath, tell your doctor. These may be symptoms of thyroid cancer. In studies with mice, Mounjaro and similar medications caused thyroid tumors, including thyroid cancer. It is not yet known whether Mounjaro causes thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC). Do not use Mounjaro if you or any of your family members have ever had medullary thyroid cancer (MTC), or if you have multiple endocrine neoplasia type 2 (MEN 2).<\/li>\n<li style=\"margin-bottom: 6px;\">Pancreatitis: Stop taking Mounjaro. If you have persistent stomach (abdominal) pain, with or without vomiting, seek medical attention immediately.<\/li>\n<li style=\"margin-bottom: 6px;\">Hypoglycemia: If you use Mounjaro together with another medication that may cause hypoglycemia\u2014such as sulfonylureas or insulin\u2014your risk of hypoglycemia may be higher. Signs and symptoms may include: dizziness; blurred vision; anxiety, irritability, or mood changes; sweating; slurred speech; hunger; confusion or drowsiness; trembling; weakness; headache; rapid heartbeat; and a tingling sensation.<\/li>\n<li style=\"margin-bottom: 6px;\">Allergic Reactions: If you experience any symptoms of a severe allergic reaction, stop using this product and seek medical attention. These symptoms include: swelling of the face, lips, tongue, or throat; difficulty breathing or swallowing; severe rash or itching; fainting or dizziness; and a rapid heartbeat.<\/li>\n<li style=\"margin-bottom: 6px;\">Kidney Problems: For people with kidney problems, diarrhea, nausea, and vomiting can lead to fluid loss (dehydration), which can worsen their kidney condition. It is important to drink clear liquids to reduce the risk of dehydration.<\/li>\n<li style=\"margin-bottom: 6px;\">Severe stomach problems: It has been reported that taking Mounjaro may cause stomach problems, which can sometimes be severe. If you have severe stomach problems, tell your doctor.<\/li>\n<li style=\"margin-bottom: 6px;\">Changes in vision: If you experience any changes in your vision while undergoing treatment, please inform your doctor.<\/li>\n<li>Gallbladder Problems: Some users have experienced gallbladder problems. If you experience any symptoms, tell your doctor immediately. These symptoms may include: upper abdominal pain; fever; yellowing of the skin or eyes (jaundice); and clay-colored stools.<\/li>\n<\/ol>\n<p style=\"margin: 0;\">The most common side effects include: nausea, diarrhea, loss of appetite, and vomiting.<\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">Vulnerable Populations<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">Pregnancy<\/strong><br \/>\nThere are insufficient data from pregnant women to assess the risk of drug-related major birth defects, miscarriage, or other adverse maternal or fetal outcomes. Poorly controlled gestational diabetes poses risks to both the mother and the fetus. Based on animal reproductive studies, exposure during pregnancy may pose a risk to the fetus. The drug should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. Based on AUC, reduced fetal growth and fetal abnormalities were observed in pregnant rats administered the drug during organogenesis at maternal clinical exposure levels; reduced fetal growth was also observed at clinically relevant exposure levels during organogenesis. These adverse effects on animal embryos\/fetuses are consistent with the pharmacological effects on maternal body weight and food intake.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">Breastfeeding Period<\/strong><br \/>\nThere are no data on the presence of tirzepatide in animal or human breast milk, its effects on breastfed infants, or its effects on lactation. The benefits of breastfeeding for the infant\u2019s development and health should be weighed against the mother\u2019s clinical need for Mounjaro and any potential adverse effects of Mounjaro or the mother\u2019s underlying medical condition on the breastfed infant.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">Women and men of reproductive age<\/strong><br \/>\nDue to delayed gastric emptying, the use of Mounjaro may reduce the effectiveness of oral hormonal contraceptives. This delay is greatest after the first dose and decreases over time. Patients using oral hormonal contraceptives are advised to switch to a non-oral method of contraception or to add a barrier method 4 weeks after initiation and 4 weeks after each dose escalation.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">Pediatric Medications<\/strong><br \/>\nThe safety and efficacy in pediatric patients (under 18 years of age) have not yet been established.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">Medications for the Elderly<\/strong><br \/>\nIn seven clinical trials, 1,539 (30.1%) of the treated patients were 65 years of age or older, and 212 (4.1%) had a baseline age of 75 years or older. No overall differences in safety or efficacy were detected between these patients and younger patients; however, the possibility of greater sensitivity in some older adults cannot be ruled out.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">Impaired kidney function<\/strong><br \/>\nDose adjustment is not recommended for patients with impaired renal function. No changes in the pharmacokinetics (PK) of tirzepatide were observed in subjects with impaired renal function (including end-stage renal disease [ESRD]). Monitor renal function when initiating or increasing the dose in patients with impaired renal function who report severe gastrointestinal adverse reactions.<\/p>\n<p style=\"margin: 0;\"><strong style=\"color: #1c2328;\">Liver dysfunction<\/strong><br \/>\nDose adjustment is not recommended for patients with hepatic impairment. In a clinical pharmacology study involving subjects with varying degrees of hepatic impairment, no changes in the pharmacokinetics (PK) of tirzepatide were observed.<\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">General Description, Composition, and Mechanism of Action<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<p style=\"margin: 0 0 8px;\">Mounjaro (Tirzepatide) for subcutaneous injection contains tirzepatide, a once-weekly GIP receptor and GLP-1 receptor agonist. It is a 39-amino acid modified peptide based on the GIP sequence. At positions 2 and 13, tirzepatide contains two non-coding amino acids (aminobutyric acid, Aib), a C-terminal amide, and a Lys residue at position 20, which is linked via a linker to 1,20-docosadienoic acid. The molecular weight is 4813.53 Da, and the chemical formula is C<sub>225<\/sub>H<sub>348<\/sub>N<sub>48<\/sub>O<sub>68<\/sub>\u3002<\/p>\n<p style=\"margin: 0 0 8px;\">Mounjaro is a clear, colorless to slightly yellow, sterile, preservative-free solution for subcutaneous injection. Each single-dose pen contains 0.5 milliliters of a tirzepatide solution containing 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong style=\"color: #1c2328;\">Active Ingredients<\/strong>: Tirzepatide<br \/>\n<strong style=\"color: #1c2328;\">Inactive Ingredients<\/strong>: Sodium chloride, disodium hydrogen phosphate heptahydrate, and water for injection. Hydrochloric acid and\/or sodium hydroxide solutions may be added to adjust the pH.<\/p>\n<p style=\"margin: 0;\">Tirzepatide is a GIP and GLP-1 receptor agonist; it is a 39-amino acid modified peptide containing a C20 fatty acid moiety that binds to albumin and prolongs its half-life. Tirzepatide selectively binds to and activates the GIP and GLP-1 receptors, which are the natural targets of GIP and GLP-1. Tirzepatide enhances first- and second-phase insulin secretion and reduces glucagon levels, both of which occur in a glucose-dependent manner.<\/p>\n<\/div>\n<\/section>\n<section class=\"mj-sec\" style=\"margin: 0 0 22px;\">\n<h3 class=\"mj-h\" style=\"margin: 0 0 10px; padding: 0 0 8px; border-bottom: 1.5px solid #2c5a52; font-family: 'Noto Serif JP','Songti TC','PMingLiU',serif; font-size: 17px; font-weight: bold; color: #1c2328;\">Patient Information<\/h3>\n<div class=\"mj-panel\" style=\"background: #f3efe8; border: 1px solid #e4dfd6; border-radius: 14px; padding: 16px 18px; color: #5e6560; font-size: 14px; line-height: 1.8;\">\n<ol style=\"margin: 0; padding-left: 20px;\">\n<li style=\"margin-bottom: 6px;\">Before using this medication, tell your doctor about all of your medical conditions, including whether you: have or have had problems with your pancreas or kidneys; have serious stomach problems, such as slow gastric emptying (gastroparesis) or difficulty digesting food; have a history of diabetic retinopathy; or are pregnant or planning to become pregnant. It is not known whether this medication could harm an unborn baby; if you become pregnant while taking this medication, tell your doctor. Oral contraceptives may be less effective while taking this medication. If you are taking oral contraceptives, your doctor may recommend an alternative method of birth control for the first 4 weeks after starting this medication and for 4 weeks after each dose increase. You are breastfeeding or planning to breastfeed. It is not known whether this medication passes into breast milk; consult your doctor about the best way to feed your baby.<\/li>\n<li style=\"margin-bottom: 6px;\">Tell your doctor about all the medications you are taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements. Mounjaro may affect how certain medications work, and certain medications may also affect how Mounjaro works.<\/li>\n<li style=\"margin-bottom: 6px;\">Before using this medication, tell your doctor if you are taking any other medications for diabetes, including insulin or sulfonylureas, as these medications may increase your risk of hypoglycemia.<\/li>\n<li>Do not use Mounjaro to treat conditions not for which it is prescribed. Do not give Mounjaro to anyone else, even if they have the same symptoms as you. Doing so could harm them.<\/li>\n<\/ol>\n<\/div>\n<\/section>\n<div class=\"mj-foot\" style=\"margin: 8px 0 0; padding: 18px 8px 4px; border-top: 1px solid #e4dfd6; text-align: center; color: #7a2e2e; font-size: 13px; line-height: 1.7;\">\u203b This page is compiled based on publicly available product information and is not a substitute for a doctor\u2019s prescription or the manufacturer\u2019s instructions.<\/div>\n<\/div>\n<\/article>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u6d77\u5916\u76f4\u90f5\uff5cGIP\uff0fGLP-1 Mounjaro \u66ff\u723e\u6cca\u80bd\u6ce8\u5c04\u6db2 Mounjaro\u00ae\uff08Tirzepatide\uff09 <\/p>\n<div class=\"klb-readmore post-buttons\"><a class=\"button rounded primary\" href=\"https:\/\/hkeemall.com\/en\/1787813600-2\/\">Read More <i class=\"klbth-icon-right-arrow\"><\/i><\/a><\/div>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[181],"class_list":["post-5167","post","type-post","status-publish","format-standard","hentry","category-news","tag-blog"],"_links":{"self":[{"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/posts\/5167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/comments?post=5167"}],"version-history":[{"count":14,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/posts\/5167\/revisions"}],"predecessor-version":[{"id":7434,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/posts\/5167\/revisions\/7434"}],"wp:attachment":[{"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/media?parent=5167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/categories?post=5167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hkeemall.com\/en\/wp-json\/wp\/v2\/tags?post=5167"}],"curies":[{"name":"Well played","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}